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Lutein Attenuates Light-induced Visual Impairment

In a study involving mice, a diet supplemented by lutein was found to attenuate light-induced photodamage of the retina. After exposure to light, reductions in a-wave and b-wave amplitudes were found (according to electroretinogram), indicating visual impairment and thinning of the photoreceptor cell layer were found, and treatment with lutein attenuated these effects. Furthermore, lutein was found to induce the expression of eyes absent (EYE), which promotes DNA repair and cell survival, and therefore could suppress DNA damage and photoreceptor cell apoptosis. The authors conclude, "The lutein-supplemented diet attenuated light-induced visual impairment by protecting the photoreceptor cells' DNA."


"Biological role of lutein in the light-induced retinal degeneration," Sasaki M, Yuki K, et al, J Nutr Biochem, 2011 June 8; [Epub ahead of print]. (Address: Laboratory of Retinal Cell Biology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan).

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