Raynaud’s Disease
Also indexed as: Raynaud’s Syndrome
Fingertips that feel tender or numb after being exposed to chilly temperatures may point to Raynaud’s disease. According to research or other evidence, the following self-care steps may provide relief:
- Fight back with fish oil
- Reduce the severity of blood vessel spasm by taking a daily supplement supplying 4 grams of eicosapentaenoic acid (EPA) for 6 to 12 weeks; after that, ask your healthcare provider to recommend an amount for long-term supplementation
- Discover inositol hexaniacinate
- With the supervision of a knowledgeable healthcare provider, take 3 to 4 grams a day of this form of vitamin B3 to reduce arterial spasm and improve peripheral circulation
- Say good-bye to smoking
- Kick the habit to avoid the damaging effects of nicotine on blood flow
- Keep in the heat
- Avoid unnecessary exposure to cold and dress warmly to prevent attacks of Raynaud’s disease
These recommendations are not comprehensive and are not intended to replace the advice of your doctor or pharmacist. Continue reading the full Raynaud’s disease article for more in-depth, fully-referenced information on medicines, vitamins, herbs, and dietary and lifestyle changes that may be helpful.
About Raynaud’s disease
Raynaud’s disease is a condition caused by constriction and spasms of small arteries, primarily in the hands after exposure to cold. Frequently, white or bluish discoloration of the hands (and sometimes toes, cheeks, nose, or ears) will occur after exposure to cold or emotional stress.
The cause of Raynaud’s disease is unknown. A condition called Raynaud’s phenomenon causes similar symptoms, but it is the result of connective tissue disease or exposure to certain chemicals. The same natural remedies are used to treat both disorders.
Product ratings for Raynaud’s disease
| Science Ratings | Nutritional Supplements | Herbs |
|---|---|---|
 |
Fish oil Inositol hexaniacinate (vitamin B3) |
|
 |
Evening primrose oil L-carnitine Magnesium |
Ginkgo |
| See also: Homeopathic Remedies for Raynaud’s disease | ||
 Reliable
and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies
suggesting a health benefit or minimal health benefit. For an herb, supported by traditional use but minimal
or no scientific evidence. For a supplement, little scientific support and/or minimal health
benefit. |
||
What are the symptoms?
Fingers (generally not the thumb) or other affected parts of the body may feel numb or cold during an episode, and later, after warming, may become bright red with a throbbing painful sensation.
Lifestyle changes that may be helpful
Dressing warmly and wearing gloves or mittens often help prevent attacks of Raynaud’s disease. Individuals with Raynaud’s disease should not smoke, because nicotine decreases blood flow to the extremities. Women with Raynaud’s disease should not use birth control pills, as this method of contraception can adversely affect circulation.
Other therapies
In severe cases, sympathectomy (surgical interruption of sympathetic nerve pathways) may be recommended. People with Raynaud’s disease are commonly advised to dress warmly during the winter and to avoid tobacco use and unnecessary exposure to cold, especially of the affected parts.
Vitamins that may be helpful
In a double-blind trial, supplementation with 12 large capsules of fish oil per day (providing 4 grams of eicosapentaenoic acid [EPA] per day) for 6 or 12 weeks reduced the severity of blood-vessel spasm in 5 of 11 people with Raynaud’s phenomenon.1 Fish oil was effective in people with primary Raynaud’s disease, but not in those whose symptoms were secondary to another disorder.
Inositol hexaniacinate—a variation on the B vitamin niacin—has been used with some success for relieving symptoms of Raynaud’s disease.2 In one study, 30 people with Raynaud’s disease taking 4 grams of inositol hexaniacinate each day for three months showed less spasm of their arteries.3 Another study, involving six people taking 3 grams per day of inositol hexaniacinate, again showed that this supplement improved peripheral circulation.4 People taking this supplement in these amounts should be under the care of a doctor.
Fatty acids in evening primrose oil (EPO) inhibit the formation of biochemical messengers (prostaglandins) that promote blood vessel constriction. A double-blind trial of 21 people with Raynaud’s disease found that, compared with placebo, supplementation with EPO reduced the number and severity of attacks despite the fact that blood flow did not appear to increase.5 Researchers have used 3,000–6,000 mg of EPO per day.
In one study, 12 people with Raynaud’s disease were given L-carnitine (1 gram three times a day) for 20 days.6 After receiving L-carnitine, these people showed less blood-vessel spasm in their fingers in response to cold exposure.
Abnormalities of magnesium metabolism have been reported in people with Raynaud’s disease.7 Symptoms similar to those seen with Raynaud’s disease occur in people with magnesium deficiency,8 probably because a deficiency of this mineral results in spasm of blood vessels.9 Some doctors recommend that people with Raynaud’s disease supplement with 200–600 mg of magnesium per day, although no clinical trials support this treatment.
Are there any side effects or interactions?
Refer to the individual supplement for information about any side effects or interactions.
Herbs that may be helpful
Ginkgo biloba has been reported to improve the circulation in small blood vessels.10 For that reason, some doctors recommend ginkgo for people with Raynaud’s disease. One preliminary trial found that 160 mg of standardized ginkgo extract per day reduced pain in people with Raynaud’s disease.11 Larger clinical trials are needed to confirm ginkgo’s effectiveness for this condition. Ginkgo is often used as a standardized extract (containing 24% ginkgo flavone glycosides and 6% terpene lactones). Doctors who recommend use of ginkgo often suggest that people take 120–160 mg per day.
Are there any side effects or interactions?
Refer to the individual herb for information about any side effects or interactions.
References
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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires September 2008.