Andrographis
Common names: Chiretta, Chuan xin lian, Kalmegh, Kirata
Botanical name: Andrographis paniculata
© Martin Wall
Parts used and where grown
Andrographis originated in the plains of India, and it also grows in China. The leaves and flowers are used medicinally.
Andrographis has been used in connection with the following conditions (refer to the individual health concern for complete information):
| Science Ratings | Health Concerns |
|---|---|
 |
Common cold Immune function Infection |
 |
Dysentery |
 |
HIV infection Indigestion Viral hepatitis |
| Reliable
and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies
suggesting a health benefit or minimal health benefit. For an herb, supported by traditional use but minimal
or no scientific evidence. For a supplement, little scientific support and/or minimal health
benefit. |
|
Historical or traditional use (may or may not be supported by scientific studies)
Andrographis has long been used in traditional Indian and Chinese herbal medicine. The most common reported uses were for digestive problems (as is the case with most non-toxic bitter herbs such as andrographis), snakebite, and infections ranging from malaria to dysentery.1 2 Interestingly, some of these uses have been validated by modern scientific research. Although the roots were sometimes used in traditional medicine, the leaves and flowers are now more commonly used.
Active constituents
The major constituents in andrographis are diterpene lactones known as andrographolides. These bitter constituents are believed to have immune-stimulating, anti-inflammatory, fertility-decreasing, liver-protective, and bile secretion-stimulating actions.3 Though some older studies suggested andrographis was antibacterial, modern research has been unable to confirm this finding.4
Several double-blind clinical trials have found that andrographis can help reduce symptom severity in people with common colds.5 6 7 8 9 Though the earliest clinical trial among these showed modest benefits, later studies have tended to be more supportive. Standardized andrographis extract combined with eleuthero (Siberian ginseng), known as Kan jang, has also been shown in a double-blind clinical trial to reduce symptoms of the common cold.10
A preliminary uncontrolled study using isolated andrographolide found that while it tended to decrease viral load and increase CD4 lymphocyte levels in people with HIV infection, at the amount used, the preparation led to side effects, including headache, fatigue, a bitter/metallic taste in the mouth, and elevated liver enzymes (which returned to normal after the medication was stopped).11 It is unknown whether the andrographolides used in this study directly killed HIV or had an immune-strengthening effect.
Andrographis has proven helpful in combination with antibiotics for people with dysentery, a severe form of diarrhea.12 It has also shown preliminary benefit for people with chronic viral hepatitis.13
How much is usually taken?
Andrographis is generally available as capsules with dried herb or as standardized extracts (containing 11.2 mg andrographolides per 200 mg of extract). For dried herb, 500–3,000 mg are taken three times per day. In clinical trials, 100 mg of a standardized extract were taken two times per day to treat the common cold.14 For indigestion, andrographis may be taken as a tea. Use 1 teaspoon (5 grams) of the herb for each cup (250 ml) of hot water. Allow the mixture to stand for 10–15 minutes before drinking (sip before meals).
Are there any side effects or interactions?
Some people develop intestinal upset when taking andrographis. If this occurs, reduce the amount taken or take it with meals. Headache, fatigue, a bitter/metallic taste, and elevated liver enzymes were reported in one trial with HIV-infected people taking high doses of isolated andrographolides.15 This has not been reported in people using whole andrographis or standardized extracts at the amounts recommended above. As with all bitter herbs, andrographis may aggravate ulcers and heartburn. The safety of andrographis during pregnancy and breast-feeding is unknown.
At the time of writing, there were no well-known drug interactions with andrographis.
References
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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires September 2008.