Beta-Sitosterol
Beta-sitosterol is one of a group of organic compounds found in plants that, alone and in combination with similar plant sterols, reduces blood levels of cholesterol.1 2 3
Where is it found?
Beta-sitosterol is one of several plant sterols (cholesterol is the main animal sterol) found in almost all plants. High levels are found in rice bran, wheat germ, corn oil, and soybeans. Peanuts and its products, such as peanut oil, peanut butter, and peanut flour, are good sources of plant sterols, particularly beta-sitosterol.4
Beta-sitosterol has been used in connection with the following conditions (refer to the individual health concern for complete information):
| Science Ratings | Health Concerns |
|---|---|
 |
Benign prostatic hyperplasia |
 |
High cholesterol |
 |
Athletic performance (in combination with beta-sitosterol glucoside for reducing the risk of post-exercise infection) |
| Reliable
and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies
suggesting a health benefit or minimal health benefit. For an herb, supported by traditional use but minimal
or no scientific evidence. For a supplement, little scientific support and/or minimal health
benefit. |
|
Who is likely to be deficient?
Because beta-sitosterol is not an essential nutrient, deficiencies do not occur.
How much is usually taken?
Between 500 mg and 10 grams of beta-sitosterol per day have been used in clinical research to reduce elevated blood cholesterol levels. Between 60 (20 mg three times per day) and 130 mg per day have been used in trials reporting a reduction in prostatic hyperplasia-related symptoms.5 6
Are there any side effects or interactions?
Ingesting plant sterols interferes with beta-carotene and vitamin E absorption, resulting in lower blood levels of these nutrients.7
At the time of writing, there were no well-known drug interactions with beta-sitosterol.
References
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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires September 2008.