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Vitamin Supplementation may Reduce Mortality and Recurrence Risks in Women undergoing Breast Cancer Treatment

In a population-based prospective cohort study involving 4,877 women, aged 20-75 years, diagnosed with invasive breast cancer, results indicate that supplementation with vitamins E, C and multivitamins shortly after diagnosis, may be associated with reduced risks of mortality and recurrence. During a mean follow-up of 4.1 years, 444 deaths and 532 recurrences were recorded. After adjusting for confounders, supplementation with vitamins E, C, and multivitamins was associated with an 18% reduced risk of mortality and a 22% reduced risk of recurrence in patients who did not receive radiotherapy, but whose vitamin use was concurrent or non-concurrent with chemotherapy. Thus, the authors of this study conclude, "Vitamin supplement use in the first six months after breast cancer diagnosis may be associated with reduced risk of mortality and recurrence. Our results do not support the current recommendation that breast cancer patients should avoid use of vitamin supplements. "


"Vitamin supplement use during breast cancer treatment and survival: a prospective cohort study," Nechuta S, Shu XO, et al, Cancer Epidemiol Biomarkers Prev, 2010 Dec 21; [Epub ahead of print]. (Address: Xiao-Ou Shu, Division of Epidemiology, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 600, IMPH, Nashville, TN, 37203-1738, United States. E-mail: xiao-ou.shu@vanderbilt.edu ).

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