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Vitamin K Deficiency Linked to Inflammation in Patients with Inflammatory Bowel Disease

In a study involving 87 patients with inflammatory bowel disease (47 with Crohn's disease and 40 with ulcerative colitis), serum undercarboxylated osteocalcin levels were significantly higher in patients with Crohn's disease, suggesting bone vitamin K insufficiency, and this was associated with clinical activity index of Crohn's disease. Vitamin D status (levels of 1,25 dihydroxyvitamin D) was also found to be significantly lower in patients with Crohn's disease and those with ulcerative colitis, as compared to healthy subjects, and these levels were inversely associated with BMD in patients with ulcerative colitis. The authors conclude, "Vitamins K and D are insufficient in patients with IBD. Insufficiency of vitamin K is suggested to be associated with inflammatory processes of CD."


"Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease," Nakajima S, Iijima H, et al, Nutrition, 2011 April 8; [Epub ahead of print]. (Address: Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan).

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