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Vitamin D Supplementation May Reduce Insulin Resistance in Women

In a randomized, placebo-controlled, double-blind study involving 81 insulin resistant South Asian women with vitamin D deficiency (serum 25(OH)D < 50 nmol/L), aged 23-68 years, results indicate that vitamin D supplementation may improve insulin resistance and insulin sensitivity. The women were randomized to 100 mug vitamin D3 (n=42) or placebo (n=39) for a period of 6 months. Significant improvements in insulin resistance and insulin resistivity were observed in the vitamin D supplemented group, compared with the placebo group, with optimal improvement associated with serum 25(OH)D levels >/= 80 nmol/L. Thus, the authors of this study conclude, “Improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion. Optimal vitamin D concentrations for reducing IR were shown to be 80-119 nmol/l, providing further evidence for an increase in the recommended adequate levels
 
Reference:
“Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial,” von Hurst PR, Coad J, et al, Br J Nutr, 2009 Sep 28:1-
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Contributor Since:
June 19, 2008
Derrick DeSilva Jr., M.D.
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Dr. Derrick DeSilva is on the Attending Staff at the Raritan Bay Medical Center in Perth Amboy, N.J., and on the teaching faculty at JFK Medical Center in Edison, N.J.

He has lectured on various topics in medicine --nationally and internationally-- and has his own talk show called Ask the Doctor which airs on WCTC in New Jersey (1450 AM) as well as his own television show, "To Your ...