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Vitamin D Supplementation May Benefit Women With HIV

In a follow-up study involving 884 HIV-infected pregnant women, results indicate that vitamin D status may be inversely associated with disease progression, anemia and all-cause mortality. The women were followed up for a median of 69.5 months. Low vitamin D status (serum 25-hydroxyvitamin D<32 ng/mL) was significantly associated with progression to WHO HIV disease stage III or greater. Additionally, women with low vitamin D status showed a 46% increased risk of developing anemia compared to women with adequate vitamin D status. Additionally, women in the highest quintile of vitamin D status showed a 42% reduced risk of all-cause mortality. Thus, the authors of this study conclude, "If confirmed in randomized trials, vitamin D supplementation could represent a simple and inexpensive method to prolonging the time to initiation of antiretroviral therapy in HIV-infected patients, particularly in resource-limited settings."
 
Reference:
"Vitamin D status of HIV-infected women and its association with HIV disease progression, anemia, and mortality," Mehta S, Fawzi WW, et al, PLoS One, 2010; 5(1): e8770.
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June 19, 2008
Derrick DeSilva Jr., M.D.
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Dr. Derrick DeSilva is on the Attending Staff at the Raritan Bay Medical Center in Perth Amboy, N.J., and on the teaching faculty at JFK Medical Center in Edison, N.J.

He has lectured o...