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Vitamin D Status, in African Americans and Progression of Kidney Disease
In a study involving data collected from 13,328 subjects, 34% of non-Hispanic black subjects were found to have low vitamin D status (25(OH)D < 15 ng/ml), as compared to 5% of non-Hispanic white subjects. Over the course of 9.1 years, 65 subjects were found to develop end stage renal disease (ESRD). After adjusting for various potential confounders, subjects with 25(OH)D < 15 ng/ml were found to have a 2.6-fold greater incidence of ESRD, as compared to those with levels >/=15 ng/ml (incidence rate ratio: 2.64). After adjusting for various clinical covariates but not 25(OH)D, Black subjects were found to have a 2.83-fold higher risk for developing ESRD, as compared to white subjects, and after adjusting for 25(OH)D levels, this reduced the risk by 58%. The authors conclude, “Low 25(OH)D levels may account for a substantial proportion of the increased risk for ESRD experienced by black individuals.”
Reference:
“25-Hydroxyvitamin D Levels, Race, and the Progression of Kidney Disease,” Melamed ML, Astor B, et al, J Am Soc Nephrol, 2009 Oct 29
Reference:
“25-Hydroxyvitamin D Levels, Race, and the Progression of Kidney Disease,” Melamed ML, Astor B, et al, J Am Soc Nephrol, 2009 Oct 29
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Dr. Derrick DeSilva is on the Attending Staff at the Raritan Bay Medical Center in Perth Amboy, N.J., and on the teaching faculty at JFK Medical Center in Edison, N.J.
He has lectured on various topics in medicine --nationally and internationally-- and has his own talk show called Ask the Doctor which airs on WCTC in New Jersey (1450 AM) as well as his own television show, "To Your ...
He has lectured on various topics in medicine --nationally and internationally-- and has his own talk show called Ask the Doctor which airs on WCTC in New Jersey (1450 AM) as well as his own television show, "To Your ...
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