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Vitamin D and the Metabolic Syndrome in Obese Adolescents

In a study involving 80 post-menarchal adolescents (53 African-American and 27 Caucasian-American), which included a sub-group of vitamin D deficient subjects (n=14), 25(OH)D was found to be inversely associated with fasting glucose and positively associated with LDL cholesterol, independent of race and BMI. In Caucasian-Americans, 25(OH)D was inversely associated with fasting insulin, and in African-Americans, 25(OH)D was positively associated with ALT. In the subgroup of patients with vitamin D deficiency, supplementation with vitamin D was associated with improvements in fasting glucose. The authors conclude, "...serum 25(OH)D was inversely associated with fasting glucose, and vitamin D treatment had beneficial effects on fasting glucose."

Reference:

"Associations of Serum 25-Hydroxyvitamin D and Components of the Metabolic Syndrome in Obese Adolescent Females," Ashraf AP, Alvarez JA, et al, Obesity (Silver Spring), 2011 May 5; [Epub ahead of print]. (Address: Department of Pediatrics/Division of Pediatric Endocrinology and Metabolism, The Children's Hospital, University of Alabama at Birmingham, Birmingham, Alabama, USA).

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