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Supplementation with EPA and DHA may Decrease Risk of Calcium Oxalate Stone Formation

In a controlled study involving 15 healthy subjects, results indicate that long-term supplementation with EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) may decrease the risk of calcium oxalate stone formation. After a control phase (subjects consumed a standardized diet for 5 days) the subjects consumed a free diet while receiving supplementation with 900 mg EPA and 600 mg DHA, for a period of 30 days. At intervention end, relative supersaturation with calcium oxalate decreased significantly (23%) due to significantly decreased urinary oxalate excretion. Thus, the authors of this study conclude, "Results show that 30-day n-3 fatty acid supplementation effectively decreases urinary oxalate excretion and the risk of calcium oxalate crystallization."

Reference:

"Effect of n-3 Fatty Acid Supplementation on Urinary Risk Factors for Calcium Oxalate Stone Formation," Siener R, Hesse A, et al, J Urol, 2010, Dec 18; [Epub ahead of print]. (Address: Department of Urology, University of Bonn, Bonn, Germany).

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