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Sesame Oil Benefits Patients with Type 2 Diabetes

In an open label study involving 60 type 2 mild-to-moderate diabetic patients divided into 3 groups (Group1 - sesame oil, approximately 35 g/d used in cooking or on salads; Group2 - 5 mg/d glibenclamide, an oral anti-diabetic drug; Group3 - combination of sesame oil and glibenclamide), for a period of 60 days, the combination treatment (sesame oil plus glibenclamide) was found to yield the best results, reducing blood glucose levels by 36% and HbA(1c) by 43%, after 60 days. Furthermore, reductions in plasma total cholesterol, LDL-cholesterol, and triglyceride levels were found in subjects in the sesame oil group (20%, 34% and 14%, respectively) and combination therapies group (22%, 38%, and 15%, respectively) after the 60 day intervention. Moreover, HDL cholesterol improved among subjects in the sesame oil group (15.7%) and combination therapies group (17%), as did the activity of enzymatic and non-enzymatic antioxidants. The authors conclude, "Sesame oil exhibited sy nergistic effect with glibenclamide and can provide a safe and effective option for the drug combination that may be very useful in clinical practice for the effective improvement of hyperglycemia."


"Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus," Sankar D, Ali A, et al, Clin Nutr, 2010 Dec 15; [Epub ahead of print]. (Address: Department of Biotechnology, AVIT, Vinayaka Missions University, Paiyanoor 603 104, Chennai, Tamilnadu, India. E-mail: devsankara@yahoo.co.in ).

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