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Probiotics Enhance Eradication of H. Pylori and Reduce Side Effects of Conventional PPI-based Triple Therapy

In a randomized study involving 991 subjects infected with Helicobacter pylori (HP), supplementation with probiotics (Saccharomyces boulardii) added to conventional proton pump inhibitor (PPI)-based triple therapy, was found to increase HP eradication rates (71.6% with PPI-based triple therapy alone vs. 80% with PPI-based triple therapy + probiotics) and reduce side effects (63/331 in PPI-based triple therapy alone group vs. 48/330 in PPI-based triple therapy + probiotics group, vs. 30/330 in PPI-based triple therapy + probiotics + mucoprotective agent group), suggesting that,"supplementation with S. boulardii could be effective for improving HP eradication rates by reducing side effects thus helping completion of eradication therapy."
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