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Plasma Vitamin C Levels Lower in Women with Preterm Prelabor Rupture of Membranes

In a prospective, cross-sectional, 2-phase study, women who experienced preterm prelabor rupture of membranes (PPROM) were found to have significantly lower plasma vitamin C levels, as compared to women without PPROM (0.53 vs 0.58 mg/dL). A significant association was found between low vitamin C levels and occurrence of PPROM. In addition, the researchers found that plasma vitamin C concentrations decreased with increasing gestational age of pregnancy. The authors conclude, "...improved dietary or drug supplements may be a useful adjunctive strategy to reducing the incidence of PPROM and its attendant adverse sequelae. While this intervention is advocated, further multicentre investigation of the effects of vitamin C on risk of preterm PROM is suggested."


"Plasma vitamin C levels and risk of preterm prelabour rupture of membranes," Osaikhuwuomwan JA, Okpere EE, et al, Arch Gynecol Obstet, 2010 Nov 3; [Epub ahead of print]. (Address: Department of Obstetrics and Gynaecology, College of Health Sciences, University of Benin, Benin City, Nigeria. E-mail: jagbons1@yahoo.com ).

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