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High Intake of Dietary Fiber may Reduce the Risk of Ovarian Cancer, whereas a High Glycemic Load Diet May Increase Risk of Ovarian Cancer

In a case-control study involving 1,366 women with ovarian cancer and 1,414 population controls, results indicate that adherence to diets with a high glycemic load (GL) may increase the risk of ovarian cancer, whereas adherence to diet rich in fiber may lower the risk of ovarian cancer. The highest quartile for GL was associated with a 24% increased risk of ovarian cancer, compared with the lowest quartile (the association was strongest among overweight/obese women). On the other hand, the highest quartile for fiber intake was associated with a 22% reduced risk of ovarian cancer, compared with the lowest quartile of intake. Thus, the authors of this study conclude, "Our results suggest that diets with a high GL may increase the risk of ovarian cancer, particularly among overweight/obese women, and a high intake of fiber may provide modest protection."

Reference:

"Carbohydrate intake, glycemic load, glycemic index, and risk of ovarian cancer," Nagle CM, Webb PM, et al, Ann Oncol, 2010 Dec 3; [Epub ahead of print]. (Address: Gynaecological Cancer Group, Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Australia).

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