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Coenzyme Q10 May Protect the Kidneys in Type 2 Diabetes Mellitus

In a study involving an experimental mouse model of type 2 diabetic nephropathy, oral administration of ubiquinone (coenzyme Q10, 10 mg/kg/d) was found to have renoprotective effects. Specifically, in diabetic mice not treated with coenzyme Q10, urinary albumin excretion level was elevated as was the albumin:creatinine ratio, which was not the case in mice treated with CoQ10. Furthermore, coenzyme Q10 was found to significantly decrease the diabetes-induced increases in total renal collagen, and to attenuate the excess renal mitochondrial hydrogen peroxide production and increased mitochondrial membrane potential found in diabetic mice. The authors conclude, "Our results suggest that a deficiency in mitochondrial oxidized CoQ10 (ubiquinone) may be a likely precipitating factor for diabetic nephropathy. Therefore CoQ10 supplementation may be renoprotective in type 2 diabetes, via preservation of mitochondrial function."

Reference:

"Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes," Sourris KC, Harcourt BE, et al, Free Radic Biol Med, 2011 Nov 21; [Epub ahead of print]. (Address: Glycation and Diabetes Complications, Baker IDI Heart Research Institute, Melbourne, VIC 3004, Australia).

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