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New Study: The Remarkable Effects of Fat Loss on Your Immune System


There is a group of scientists in Australia that have proven that moderate weight loss can reverse many of the damaging changes that occur in immune cells. This particularly holds true for obese people with type-2 diabetes. Let's take a closer look at this recent research.

Your immune system is made up of many different kinds of cells. These cells protect your body from germs, viruses, and other invaders. The cells do need to co-exist with balance and order. This is how we maintain good health.  Diet and excess body fat are two factors that can tip the balance and order. If diet is poor and body fat is excessive you can create immune cells that attack your body instead of defending it.

The knowledge that excess body fat in the abdominal region can trigger the production of pro-inflammatory immune cells has been known for some time. Those cells circulate in the blood and cause damage to your body as a whole.  That causes macrophage pro-inflammatory immune cells to also activate within the fat tissue.  People with type-2 diabetes seem to be prone to this.

Details of the Study
A recent study, conducted by Sydney’s Garvan Institute of Medical Research looked at individuals who were obese and had type-2 diabetes. The subjects were limited to a diet that ranged from 1000 to 1600 calories a day, and which lasted for 24 weeks. Halfway through the diet gastric banding was performed to help restrict the food intake for the second half of the study.  The reason was that they wanted to determine the effects of weight loss on different immune cells in the body. The researchers found that there was nearly an 80% reduction in the pro-inflammatory cells. There was also a reduced activation of various other circulating immune cells and a decrease in the macrophage pro-inflammatory cells in the body fat.

When people are suffering from a pro-inflammatory condition weight loss does seem to help. An average of ten pounds is enough to bring most people out of the pro-inflammatory stage for their immune cells. In turn, they return to a state that is more similar to lean people’s cells. This is so important because the inflammatory cells do promote coronary artery disease; plus, a variety of other illnesses that are associated with obesity.

Other research also shows that the activation of immune cells found in fat can help predict weight gain in people or how much weight they could lose following a calorie restricted diet. The diet is most often combined with a bariatric surgery. The more activated the immune cell – the less the weight loss. This information is very helpful in determining why some individuals seem to lose weight so much easier than others when they are on similar weight loss plans.

Weights that are considered excessive now have an impact on nearly 50% of adults in Australia and possibly more in the United States. Since obesity is the number one cause of type-2 diabetes and certain cancers it is important to get excess body fat under control. While the process may not be easy it is critical. There is no denying that excess fat will affect a person’s immune system and in the end that excess fat effects their survival.

Do your part in keeping your immune system healthy. Reduce your body fat to a healthy level and eat the right foods to maintain that level.

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